Correlation of Serum Cystatin C to Serum Creatinine in Haemodialysis Patients
Abstract
ABSTRACT
Background: Cystatin C is a better marker of the glomerular filtration rate and hence of kidney function than creatinine which was the most commonly used measure of kidney function.
Objectives: To assess serum cystatin C compared with creatinine as markers of renal function in hemodialysis patients before and after dialysis in comparison with healthy subjects.
Methods: The present study is a case-control study conducted during the period from October, 2009 till the end of December 2009, which includes measurement of serum creatinine by enzymatic method and cystatine C by High Pressure Liquid Chromatography method on 40 patients with Renal Failure on regular hemodialysis attending the Dialysis Unit at Al-Kadhimiya Teaching Hospital with a matching group of 40 apparently volunteer subjects for age and sex which were considered as a control.
Results: The serum (creatinine and cystatine C) are significantly elevated in HD patients (pre- and post- dialysis) (P<0.001) as compared with controls; however, these parameters are reduced significantly (P<0.001) in post-dialysis patients when compared with predialysis patients. Both creatinine and cystatine-C are significantly correlated (r=0.9, P<0.001 in all study groups whether HD or control groups.
Conclusion: All hemodialysis patients have impaired renal function. This is supported by the finding of high serum (creatinine and cystatin-C) which are markers of renal function. A cystatine-C measurement in serum is more preferable than serum creatinine as it is not affected by age or muscle mass. Serum Cys-C had higher diagnostic value and more practicable than serum creatinine for identification of impaired renal function in hemodialysis patients and general population
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