SURGERY SURGERY OF LIVER HYDATIDOSIS WITH AND WITHOUT ALBENDAZOLE
Hepatic hydatidosis still remains a serious problem in general surgery. Recurrence and/or secondary hydatidosis rates are up to 25% in the cases treated with surgery alone. Albendazole is the most commonly used drug in the dual treatment of echinococcosis.
The aim of the present study was to evaluate the effect of albendazole using the intraoperative and perioperative periods as dual therapy on recurrence of echinococcosis.
Eighty-eight patients with hydatid disease who were operated upon for hepatic hydatid cysts between 1 March 1998 and 31 July 2006, in the Surgical Department of the Erbil Teaching Hospital in Erbil City (2,5 million population) Iraq, are included in this study. The patients were divided into two groups. The first group was treated with Albendazole Peri and intraoperatively with surgery while the second (Comparison) group was treated surgically alone and without Albendazole. Perioperative albendazole treatment was given in a dose of 12–15mg/kg/day in four divided doses. The treatment was started 2–28 days before the surgery when the diagnosis was established and was continued for one month.
Results showed that 36% of scolices were viable in the treated group, while 80% of scolices were viable in the second (comparison) group (P < 0.005). In the second (comparison) group there were four patients with sterile cysts and 15 patients with fertile and viable cysts but with no daughter cysts. In the treated patients there were only 3 (9%) with recurrent cysts that developed in the previous surgical field, compared with the second (comparison) group, where there were 13 patients (24%) who developed recurrent cysts
Copyright (c) 2007 Iraqi Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Share — copy and redistribute the material in any medium or format
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.