Identification of Possible Association between Helicobacter pylori Infection and Preeclampsia Incidence Miami Abd-Al Hassan* FICOG, Ekhlass Hussam Sabri Al-Rawi* FICOG CABOG, Zanan Abdulhameed Odhar MBChB

  • imj Iraq Medical Journal
Keywords: Preeclampsia, Helicobacter pylori, Anti H. pylori IgG, type 1 helper cell, Anti-CagA Ab, Pregnancy


Background: Preeclampsia is a multi-systemic hypertensive disorder that adversely influences maternal, fetal and neonatal outcomes. The pathophysiology and primary triggers of this syndrome is not entirely understood. Recently, it was suggested that infection with certain pathogenic microorganisms can contribute to preeclampsia pathophysiological pathway as initial causative factor.

Objective: To investigate the possibility of an association between PE incidence and Helicobacter pylori infection and any adverse pregnancy outcome.

Methods: A case-control study at the Department of Obstetrics and Gynecology at AlYarmouk Teaching Hospital from April to December 2017. We utilized immunochromatographic analysis to screen 40 pregnant women with preeclampsia (case group) and another 50 normotensive pregnant women with comparable gestational age (control group) for serum IgG antibodies against Helicobacter pylori. Serological screening was also carried out to examine blood samples collected from umbilical cord vessels for 24 pregnant women of preeclampsia group after delivery in order to diagnose transplacental transfer of anti- Helicobacter pylori IgG antibodies. Results: the seropositivity of IgG antibodies against Helicobacter pylori was significantly higher in pre-eclamptic women (72.5%) than in control group (36%) (P value = 0.0006; Odds ratio = 4.687; 95% confidence interval = 1.9 - 11.56). No significant association had been reported between severity of preeclampsia and Helicobacter pylori IgG seropositivity (P value = 0.4507). Regarding blood samples analysis of umbilical cord vessels for 24 women of case group, most of seropositive pre-eclamptic women (positive maternal serum) also had positive cord serum

results. This can further confirm the ability of Helicobacter pylori IgG antibodies to cross placental barrier.

Conclusion: A significant association had been observed in this study between infection with Helicobacter pylori and incidence of preeclampsia, but there was no remarkable relationship between this infection and severity of preeclampsia


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