Evaluation of the Levels of Serum Testosterone and Some Lipid Profile in Patients with Nodulocystic Acne Osama M Al-joboori* FICMS, Mohammed A Al-marsoome* FICMS, Hussain Fathel Khalel* MBChB

Keywords: Testosterone, Nodulocystic acne, Propionibacterium acnes


Background: Acne is a chronic inflammatory skin disease that occurs when dead skin cells and sebum close hair follicles. It is characterized by seborrhoea, the formation of open and closed comedones (primary lesion of acne), erythematous papules and pustules and possible scarring. Acne mainly affects skin areas with a large number of sebaceous glands, these areas include the face, back and upper chest. The outcome appearance may lead to anxiety, reduced self-esteem, in severe cases, depression and suicidal thoughts. Genetic factors play an important role (as a primary cause of acne) in about 80% of patients. The role of sunlight exposure, cigarette smoking and diet is still unclear. Overgrowth of Propionibacterium acnes (Gram-positive bacteria) which is normally found in the skin and hair follicles also play an important role in pathogenesis of acne. After puberty, in male and female, acne often appears to be an increase in hormones such as testosterone.
Objective: To assess levels of serum testosterone and some lipid profile in patients with nodulocystic acne.
Methods: This is an open, comparative, controlled investigative study. A total of sixty patients were enrolled in this study. Sixty patients were divided into 2 groups; each one consists of thirty patients: Group A: Nodulocystic acne patients. Group B: Acne vulgaris patients (pathological control).
Results: Analysis of the levels of cholesterol, triglycerides and androgen hormone (testosterone) in patients with nodulocystic acne patients and acne vulgaris patients. The results of the laboratory analysis between the two groups showed no significant difference.
Conclusion: The available results in our study showed no significant difference in the present hormonal level of testosterone and lipid profile between nodulocystic acne patients and acne vulgaris patients.