Association between Spontaneous Abortion and Human Papilloma Virus Infection in Mosul Province, Iraq May Majdi Abdulmaged* DGO

Keywords: Human papilloma virus, Pregnancy, Abortion, Mosul, Iraq.


Background: In pregnant women or in their partners, Human Papilloma Virus infection can be considered as a risk of preterm birth, abortions and virus transmission to the newborn.
Objectives: To find association between Human Papilloma Virus infection and spontaneous abortion and to detect the associated risk factors.
Methods: A case-control study that was conducted in Obstetrics and Gynecology Department of Al-Khansaa Teaching Hospital in duration of one year from Jun 2017 to May 2018. It included 60 pregnant women with spontaneous abortion (case group), and 60 pregnant women ended with viable full term pregnancy (Control group). Age < 18 years, chronic medical disease during pregnancy or multiple pregnancy, premature rupture of membrane or preterm or post term labor, history of previous three or more recurrent abortions were excluded. Human Papilloma Virus test was done by performing polymerase chain reaction test from a sample had been taken from each pregnant woman.
Results: The majority did not have Human Papilloma Virus infection (88.3%), while 11.7% had. Human Papilloma Virus infection presented in higher rate in women who had abortion that occurred in the 1st trimester (20.6%). Significant higher proportion of study patients with Human Papilloma Virus infection were ended with abortion (78.6%, P=0.022). Human Papilloma Virus infection was significantly seen among patients with previous history of abortion and in patients who currently use oral contraceptive pills (25.6%, P=0.001 and 20.5%, P=0.022 respectively).
Conclusion: Human Papilloma Virus prevalence is higher in pregnancy with spontaneous abortion compared to women experience a normal full term pregnancy. Previous history of abortion and current use of oral contraceptive pills were modifiable risk factors associated with Human Papilloma Virus infection.