Intrapleural Minocyclin Instilla Intrapleural Minocyclin Instillation Vs Bleomycin in Management of Recurrent Pleural effusion Mohammed J Jameel* FIBMS

  • imj Iraq Medical Journal
Keywords: Recurrent pleural effusion, Chemical pleurodesis, Intrapleural minocyclin instillation.


Background: Chemical pleurodesis was described to manage malignant pleural effusion, it is effective and associate with least morbidity and can be carried out as an outpatient procedure.

Objectives: To discuss uses of minocyclin as seclerosant agent to induce chemical pleurodesis in comparison to bleomycin from other studies regarding success rate, cost, side effects and acceptability.

Methods: A prospective study is carried out from February 2014 till April 2017 on 45 patients presented with recurrent pleural effusion, malignant in 29 patients (64.4%) and non malignant in 16 patients (35.6%) on an outpatient base.

Results: After 2-9 months follow up period (mean ±SD is 5 ±1.2). Intrapleural minocyclin instillation was successful in 39 patients (86.7%) as all over (successful result was reported when there was no recurrence of effusion within 30 days post instillation), no mortality reported. Reported side effects of minocyclin like chest pain in seven patients (15.5%), nausea and vomiting in five patients (11%), elevated serum bilirubin in two patients (4.4%). Recurrent effusion in six patients (13.3%).

Conclusion: Chemical pleurodesis using minocyclin instillation is safe and effective and can be carried out as an outpatient procedure. Minocyclin is one of the best materials available regarding lower side effect in comparison to bleomycin, cheap and acceptable by patients.


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