Mean Platelet Volume and Platelet Distribution Width as Predictors for Preterm Labour
Background: Preterm birth is the leading cause of perinatal death and handicap in
children and the vast majority of mortality and morbidity relates to early delivery before 36
weeks +6 days. A new noninvasive, simple marker is needed for the prediction of preterm
Objective: To determine the value of mean platelet volume (MPV) and platelet distribution
width (PDW) in the prediction of preterm delivery.
Methods: A case-control study was done in Baghdad in Al-Yarmouk teaching hospital and
private clinic in the period from 1st of January 2015 to 1st of July 2015. Hundred patients
included in the study, fifty patients with preterm labour delivered between 24 and 36
weeks +6 days (group 1) and was fifty patients of the same gestation age who delivered at
term (group 2). Blood sample collection for mean platelet volume and platelet distribution
volume measurements. Cervical dilatation, effacement and uterine contraction were
Results: The mean platelet volume was lower in group 1 than group 2 and the difference
was statistically significant (P<0.001) and platelet distribution width was higher in group1
than group 2 and the difference also was statistically significant (P<0.001).
Conclusion: Preterm labor is associated with decreased mean platelet volume and
increased platelet distribution width and they can be used as relatively a simple, reliable
marker for prediction of preterm labour.
Keywords: Preterm labour, Platelets, Mean platelet volume, Platelet distribution
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