Detection of Helicobacter pylori in Patients with Colitis (Ulcerative and Non Ulcerative)
Background: Colitis is a chronic inflammatory disorder of rectum that often extends to
involve the remainder of the large intestine in a continuous manner. Helicobacter pylori
species may be associated with the pathogenesis of ulcerative colitis in human being.
Objective: Endoscopical classification of clinically diagnosed colitis patients and studying
Helicobacter pylori in all studied groups by using serological method ELISA for their
Methods: Case-series study was conducted on 48 colitis patients (18 males and 30
females); 30 patients were diagnosed as ulcerative colitis and 18 as non ulcerative colitis
by endoscopy, histopathology and laboratory examination at Gastroenterology and
Hepatology Teaching Hospital through the period between January 2008 and June 2008.
Forty eight healthy individuals of even age and sex distribution (18 males, 30 females),
age range from (17 to 48) years who hadn’t any gastrointestinal complaints were
assessed as the control group. Blood was collected from all patients and control. General
stool examination and ELISA test for IgG anti Helicobactor pylori antibodies were
Results: This study revealed female with colitis preponderance with female: male ratio of
1.7:1, but statistically there was no significant difference (P>0.05). The mean age of
patients with colitis was 33.11years ±15.682 in age group (21-50) year.
There was a significant association between colitis (ulcerative and non ulcerative) and
endoscopic findings (P < 0.05), about 60% of patient with ulcerative colitis had proctitis,
20% left sided colitis and 20% pancolitis on endoscopy. Histological typing of ulcerative
colitis grouped into chronic ulcerative colitis (86.67%) and active on chronic ulcerative
colitis (13.33%). The highest positive results of IgG anti-Helicobacter pylori antibodies
were in non ulcerative colitis group than ulcerative colitis group (69.23%, 38.46%
respectively) with no significant association (P>0.05).
Conclusion: Endoscopy is a very important and histopathological finding is golden
standard for diagnosis of colitis .The higher positive result of IgG anti-Helicobacter pylori
antibodies were in non ulcerative colitis group (69.23%) than ulcerative colitis group
Keywords: Helicobacter pylori, Ulcerative colitis.
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