Comparison of Serum Leptin Level in Ectopic and Normal Pregnancy
Background: Leptin hormone has an important role in reproduction; its secretion
increased during pregnancy from the first trimester and decrease after parturition.
Alterations in leptin level are an indicator of cessation of pregnancy either
normally at term or due to pathology.
Objective: To assess maternal serum leptin level in women with ectopic
pregnancies and compare it with that of normal pregnant women.
Methods: A case-control study carried out in Al Emamin AlKadmain medical city,
Department of Obstetrics and Gynaecology from the first of February 2014 to the
first of January 2015. One hundred fifty pregnant females were included in this
study, seventy five women with ectopic pregnancies considered as study group
and seventy five women with singleton uncomplicated pregnancy considered as
control group with maximum gestational age in both was eight weeks. Maternal
age, gestational age, parity, body mass index and leptin levels, were recorded for
Results: The mean leptin level (ng/ml) in the study group was (15.25±2.84) while
the mean leptin level (ng/ml) in the control group was (12.51±2.11), there was
statistically significant difference between the two groups as P value < 0.0001.
There was no statistically significant difference in maternal age, parity, body mass
index in both study and control groups, but significant difference was found in
gestational age between study and control groups as P value < 0.0001. There
was a positive correlation between leptin level and body mass index in both the
study and the control groups as r value 0.504, 0.637, respectively, with
statistically significant difference as P value < 0.001 in both groups. There was no
statistically significant difference between leptin level and maternal age, parity in
both groups. While statistically significant difference was found between leptin
level and gestational age only in control group as P value 0.018.
Conclusion: Maternal serum leptin level was higher in women with ectopic
pregnancy compared to that of normal pregnancy.
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